Semantic Segmentation with Uncertainty Estimation Based on the Dirichlet Model and Anisotropic Regularization
https://doi.org/10.23947/2587-8999-2026-10-1-7-20
Abstract
Introduction. In computational mathematics, variational methods for minimizing discrete energies are widely used for the regularization of ill-posed problems. However, standard discrete schemes often suffer from scale inconsistency: upon mesh refinement (h→0), weights depending on unnormalized jumps of the function degenerate, leading to trivialization
of the anisotropic properties of the limiting operator. In this paper, a computational method is proposed that solves this problem by parameterizing the Dirichlet distribution and employing rigorously justified anisotropic spatial regularization.
Materials and Methods. The mathematical model is formulated as an optimization problem for a composite functional in the space of grid functions. The functional includes an expected logarithmic loss function, Kullback-Leibler regularization, and spatial regularizers of the weighted Dirichlet energy type. To ensure the structural consistency of the discrete operator, edge-aware weight functions are constructed strictly through normalized finite differences. The asymptotic behavior of the discrete energies is investigated using the apparatus of Γ-convergence.
Results. The main theoretical result of the work is a mathematical proof of the Γ-convergence of a family of discrete anisotropic functionals to a non-trivial continuous limit in the L²(Ω) topology. The equicoercivity of the discrete energies is proven, guaranteeing the convergence of a sequence of almost minimizers to the solution of the continuous problem.
Discussion. The use of normalized finite differences in constructing the weights restores dimensional homogeneity and ensures strict scale invariance of the discretization of non-local operators.
Conclusion. The proposed method successfully links continuous variational formulations with discrete predictive models, providing a theoretically justified and computationally efficient tool (additional inference costs amount to 17–18 %) with controlled error.
Keywords
About the Authors
E. Yu. ShchetininRussian Federation
Evgeny Yu. Shchetinin, Dr. Sci. (Phys.-Math.), Professor
Department of Information Technologies
299053; 33, Universitetskaya St.; Sevastopol
SPIN-code
A. A. Shevchuk
Russian Federation
Andrey A. Shevchuk, PhD Student
Department of Information Technologies
299053; 33, Universitetskaya St.; Sevastopol
References
1. Begoli E., Bhattacharya T., Kusnezov D. The need for uncertainty quantification in machine-assisted medical decision making. Nat Mach Intell. 2019;1(1):20–23. doi: 10.1038/s42256-018-0004-1
2. Abdar M., Pourpanah F., Hussain S., et al. A review of uncertainty quantification in deep learning: Techniques, applications and challenges. Inf Fusion. 2021;76:243–297. doi: 10.1016/j.inffus.2021.05.008
3. Gal Y., Ghahramani Z. Dropout as a Bayesian approximation: representing model uncertainty in deep learning. In: Proc. ICML. New York: PMLR; 2016. P. 1050–1059.
4. Lakshminarayanan B., Pritzel A., Blundell C. Simple and scalable predictive uncertainty estimation using deep ensembles. In: Advances in Neural Information Processing Systems. 2017;30:6402–6413.
5. Sensoy M., Kaplan L., Kandemir M. Evidential deep learning to quantify classification uncertainty. In: Advances in Neural Information Processing Systems. 2018;31:3183–3193.
6. Malinin A., Gales M. Predictive uncertainty estimation via prior networks. In: Advances in Neural Information Processing Systems. 2018;31:7047–7058.
7. Jungo A., Reyes M. Assessing reliability and challenges of uncertainty estimations for medical image segmentation. In: MICCAI 2019. LNCS, vol. 11765. Cham: Springer; 2019. P. 48–56. doi: 10.1007/978-3-030-32245-8_6
8. Nair T., Precup D., Arnold D.L., Arbel T. Exploring uncertainty measures in deep networks for multiple sclerosis lesion detection and segmentation. Med Image Anal. 2020;59:101557. doi: 10.1016/j.media.2019.101557
9. Mehrtash A., Wells W.M., Tempany C.M., Abolmaesumi P., Kapur T. Confidence calibration and predictive uncertainty estimation for deep medical image segmentation. IEEE Trans Med Imaging. 2020;39(12):3868–3878. doi: 10.1109/TMI.2020.3006437
10. Li H., Nan Y., Del Ser J., Yang G. Region-based evidential deep learning to quantify uncertainty and improve robustness of brain tumor segmentation. Neural Comput Appl. 2023;35:22071–22085. doi: 10.1007/s00521-022-08016-4
11. UDEL: Rethinking uncertainty dynamic estimation learning for ambiguous medical image segmentation. Digit Signal Process. 2025;169:105723. doi: 10.1016/j.dsp.2025.105723
12. Yang B., Zhang X., Zhang H., et al. Structural uncertainty estimation for medical image segmentation. Med Image Anal. 2025;103:103602. doi: 10.1016/j.media.2025.103602
13. Han K., Wang S., Chen J., et al., Region uncertainty estimation for medical image segmentation with noisy labels. IEEE Trans Med Imaging. 2025;44(12):5197–5207. doi: 10.1109/TMI.2025.3589058
14. Dal Maso G. An Introduction to Γ-Convergence. Boston: Birkhäuser; 1993. doi: 10.1007/978-1-4612-0327-8
15. Braides A. Γ-Convergence for Beginners. Oxford: Oxford University Press; 2002. doi: 10.1093/acprof:oso/9780198507840.001.0001
16. Ciarlet P.G. The Finite Element Method for Elliptic Problems. Philadelphia: SIAM; 2002. doi: 10.1137/1.9780898719208
17. Ronneberger O., Fischer P., Brox T. U-Net: convolutional networks for biomedical image segmentation. In: MICCAI 2015. LNCS, vol. 9351. Cham: Springer; 2015. P. 234–241. doi: 10.1007/978-3-319-24574-4_28
18. He K., Zhang X., Ren S., Sun J. Deep residual learning for image recognition. In: Proc. CVPR. 2016. P. 770–778. doi: 10.1109/CVPR.2016.90
19. Kingma D.P., Ba J. Adam: a method for stochastic optimization. In: Proc. ICLR. 2015. arXiv:1412.6980.
20. Bernard O., Lalande A., Zotti C., et al. Deep learning techniques for automatic MRI cardiac multistructures segmentation and diagnosis. IEEE Trans Med Imaging. 2018;37(11):2514–2525. doi: 10.1109/TMI.2018.2837502
21. Landman B.A., Xu Z., Iglesias J.E., et al. MICCAI Multi-Atlas Labeling Beyond the Cranial Vault ⸺ Workshop and Challenge. doi: 10.7303/syn3193805
22. Kavur A.E., Gezer N.S., Bariş M., et al. CHAOS Challenge ⸺ combined (CT-MR) healthy abdominal organ segmentation. Med Image Anal. 2021;69:101950. doi: 10.1016/j.media.2020.101950
23. Geifman Y., El-Yaniv R. Selective classification for deep neural networks. In: Advances in Neural Information Processing Systems. 2017;30:4878–4887.
24. Isensee F., Jaeger P.F., Kohl S.A.A. et al. nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation. Nat Methods. 2021;18(2):203–211. doi: 10.1038/s41592-020-01008-z
25. Perona P., Malik J. Scale-space and edge detection using anisotropic diffusion. IEEE Trans Pattern Anal Mach Intell. 1990;12(7):629–639. doi: 10.1109/34.56205
26. Bakhvalov N.S., Zhidkov N.P., Kobelkov G.M. Numerical methods. Moscow: BINOM; 2012. 636 p.
27. Johnson N.L., Kotz S., Balakrishnan N. Continuous Univariate Distributions. Vol. 2. 2<sup>nd</sup> ed. New York: Wiley; 1995. (In Russ.)
28. Tikhonov A.N., Arsenin V.Ya. Methods for solving ill-posed problems. Moscow: Nauka; 1979. 288 p. (In Russ.)
29. Samarsky A.A. The theory of difference schemes. Moscow: Nauka; 1989. 616 p. (In Russ.)
30. Chen T., Xu B., Zhang C., Guestrin C. Training deep nets with sublinear memory cost. arXiv:1604.06174. 2016.
31. Micikevicius P., Narang S., Alben J. et al. Mixed precision training. In: Proc. ICLR. 2018. arXiv:1710.03740.
Review
For citations:
Shchetinin E.Yu., Shevchuk A.A. Semantic Segmentation with Uncertainty Estimation Based on the Dirichlet Model and Anisotropic Regularization. Computational Mathematics and Information Technologies. 2026;10(1):7-20. https://doi.org/10.23947/2587-8999-2026-10-1-7-20
JATS XML









